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While amylin holds promise as a therapeutic agent, its translation into clinical practice is hampered by complex receptor biology, the limitations of animal models, its amyloidogenic properties and pharmacokinetic challenges

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0.8 mm) as the aspiration must be carried out very slowly to avoid drawing up the lymphocytes from the bottom half of the turbid layer (see Section 4, Note 4)

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To further confirm the observed Y1234/1235 phosphorylation, we performed in-cell imaging of Met phosphorylation, using the most active dimeric macrocycles, and monitoring by immunofluorescence microscopy of EHMES-1 cells (Supplementary Fig